CAS No.:66357-59-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	2400mg/kg/43W (2400mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	American Journal of Diseases of Children. Vol. 139, Pg. 442, 1985.
dog	LDLo	oral	3gm/kg (3000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of Toxicological Sciences. Vol. 8(Suppl,
man	TDLo	intravenous	714mg/kg/5M-C (714mg/kg)	CARDIAC: CHANGE IN RATE	American Journal of Gastroenterology. Vol. 83, Pg. 332, 1988.
man	TDLo	oral	8571ug/kg/2D- (8.571mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS BLOOD: EOSINOPHILIA	American Journal of Kidney Diseases. Vol. 22, Pg. 337, 1993.
man	TDLo	oral	30mg/kg/1W-I (30mg/kg)	BEHAVIORAL: HEADACHE	New England Journal of Medicine. Vol. 310, Pg. 1602, 1984.
man	TDLo	oral	87mg/kg/4D-I (87mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT CARDIAC: PULSE RATE	Annals of Internal Medicine. Vol. 108, Pg. 493, 1988.
mouse	LD50	intramuscular	400mg/kg (400mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
mouse	LD50	intraperitoneal	300mg/kg (300mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
mouse	LD50	intravenous	60mg/kg (60mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences. Vol. 8(Suppl,
mouse	LD50	oral	1100mg/kg (1100mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Toxicological Sciences. Vol. 8(Suppl,
mouse	LD50	subcutaneous	630mg/kg (630mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rabbit	LD50	intravenous	109mg/kg (109mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rabbit	LD50	oral	2500mg/kg (2500mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat	LD50	intramuscular	1530mg/kg (1530mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat	LD50	intraperitoneal	441mg/kg (441mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
rat	LD50	intravenous	85mg/kg (85mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Toxicological Sciences. Vol. 8(Suppl,
rat	LD50	oral	4190mg/kg (4190mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 147, 1983.
rat	LD50	subcutaneous	1700mg/kg (1700mg/kg)		Yakkyoku. Pharmacy. Vol. 36, Pg. 521, 1985.
women	TDLo	intravenous	27mg/kg/8D-I (27mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Archives of Internal Medicine. Vol. 152, Pg. 2325, 1992.
women	TDLo	multiple routes	174mg/kg/33D- (174mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	American Journal of Kidney Diseases. Vol. 22, Pg. 333, 1993.
women	TDLo	oral	3mg/kg (3mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	New England Journal of Medicine. Vol. 310, Pg. 1601, 1984.
women	TDLo	oral	9mg/kg/36H-I (9mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	American Journal of Psychiatry. Vol. 143, Pg. 257, 1985.
women	TDLo	oral	12mg/kg/2D-I (12mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Allergy. Vol. 51, Pg. 659, 1996.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information of Ranitidine hydrochloride (CAS NO.66357-59-3):
Risk Statements: 20/21/22  
20:  Harmful by inhalation 
21:  Harmful in contact with skin 
22:  Harmful if swallowed 
Safety Statements: 22-24/25
22:  Do not breathe dust 
24:  Avoid contact with skin 
25:  Avoid contact with eyes 

Standards and Recommendations：

 

Analytical Methods：