CAS No.:303-47-9

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	oral	3300ug/kg (3.3mg/kg)	CARDIAC: PERICARDITIS LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Applied Microbiology. Vol. 21, Pg. 492, 1971.
chicken	LDLo	subcutaneous	11mg/kg (11mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	Applied Microbiology. Vol. 21, Pg. 492, 1971.
domestic animals - goat/sheep	LD50	intravenous	1mg/kg (1mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES	CRC Critical Reviews in Toxicology. Vol. 2, Pg. 499, 1974.
duck	LD50	oral	500ug/kg (0.5mg/kg)	LIVER: FATTY LIVER DEGERATION	Nature. Vol. 205, Pg. 1112, 1965.
mouse	LD50	intraperitoneal	22mg/kg (22mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.
mouse	LD50	intravenous	25710ug/kg (25.71mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
mouse	LD50	oral	46mg/kg (46mg/kg)		Toxicology Letters. Vol. 25, Pg. 1, 1985.
quail	LD50	oral	16500ug/kg (16.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Poultry Science. Vol. 55, Pg. 786, 1976.
rat	LD50	intraperitoneal	12600ug/kg (12.6mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
rat	LD50	intravenous	12750ug/kg (12.75mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Annales Recherches Veterinaires. Vol. 5, Pg. 233, 1974.
rat	LD50	oral	20mg/kg (20mg/kg)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA	Food and Cosmetics Toxicology. Vol. 6, Pg. 479, 1968.
rat	LD50	unreported	22mg/kg (22mg/kg)		Indian Journal of Experimental Biology. Vol. 29, Pg. 813, 1991.
turkey	LD50	oral	5900ug/kg (5.9mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Poultry Science. Vol. 55, Pg. 786, 1976.

Consensus Reports：

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 56 , 1993,p. 489.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 , 1983,p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 56 , 1993,p. 489.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 , 1983,p. 191.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 56 , 1993,p. 489.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

SAFETY PROFILE：

Confirmed carcinogen with carcinogenic and neoplastigenic data. Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
 

Hazard Codes: T,T+,Xn,F
Risk Statements:
R11:Highly flammable. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed. 
R36:Irritating to eyes. 
R36/38:Irritating to eyes and skin. 
R39:Danger of very serious irreversible effects. 
R40:Limited evidence of a carcinogenic effect. 
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R48:Danger of serious damage to health by prolonged exposure. 
R61:May cause harm to the unborn child. 
R65:Harmful: may cause lung damage if swallowed.
Safety Statements:
S16:Keep away from sources of ignition. 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S36:Wear suitable protective clothing. 
S36/37:Wear suitable protective clothing and gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use. 
S62:If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
 

Standards and Recommendations：

 

Analytical Methods：