CAS No.:108-46-3

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	subcutaneous	110mg/kg (110mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913.
dog	LDLo	intravenous	700mg/kg (700mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	parenteral	270mg/kg (270mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
guinea pig	LDLo	subcutaneous	400mg/kg (400mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: TETANY BEHAVIORAL: COMA	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
human	LDLo	oral	29mg/kg (29mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 519, 1969.
mouse	LD50	intraperitoneal	215mg/kg (215mg/kg)		Bulletin of Experimental Biology and Medicine Vol. 61, Pg. 291, 1966.
mouse	LD50	oral	200mg/kg (200mg/kg)		Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse	LD50	subcutaneous	213mg/kg (213mg/kg)		Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. Vol. 2, Pg. 333, 1947.
rabbit	LD50	skin	3360mg/kg (3360mg/kg)	SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE	American Industrial Hygiene Association Journal. Vol. 37, Pg. 596, 1976.
rat	LCLo	inhalation	160mg/m3/1H (160mg/m3)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 11-4/1970,
rat	LD50	oral	301mg/kg (301mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 11-4/1970,
rat	LDLo	subcutaneous	400mg/kg (400mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: TETANY BEHAVIORAL: COMA	Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,  N
Risk Statements:
22:  Harmful if swallowed 
50:  Very Toxic to aquatic organisms    
36/38:  Irritating to eyes and skin 
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
61:  Avoid release to the environment. Refer to special instructions safety data sheet 

Standards and Recommendations：

 

Analytical Methods：