CAS No.:65-45-2

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
cat	LDLo	oral	150mg/kg (150mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
dog	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
guinea pig	LD50	oral	1730mg/kg (1730mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
guinea pig	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse	LD50	intraperitoneal	180mg/kg (180mg/kg)		Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
mouse	LD50	intravenous	313mg/kg (313mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
mouse	LD50	oral	300mg/kg (300mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse	LD50	subcutaneous	300mg/kg (300mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
rabbit	LD50	oral	3200mg/kg (3200mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
rabbit	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951.
rat	LD50	intraperitoneal	600mg/kg (600mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953.
rat	LD50	oral	980mg/kg (980mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 22-36/37/38-20/21/22 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: VN6475000
HazardClass: 6.1(b)
PackingGroup of Salicylamide (CAS NO.65-45-2): III

Standards and Recommendations：

 

Analytical Methods：