CAS No.:18883-66-4

TOXICITY DATA with REFERENCE：

 Streptozoticin (18883-66-4) has been listed as a carcinogen by NTP: Suspect carcinogen and IARC: Group 2B carcinogen. Its result of Ames-test is positive. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	50mg/kg (50mg/kg)		Journal of Medicinal Chemistry. Vol. 19, Pg. 918, 1976.
human	TDLo	intravenous	1044mg/kg/5D (1044mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Cancer Vol. 34, Pg. 993, 1974.
monkey	LDLo	intravenous	80mg/kg (80mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Drug and Chemical Toxicology. Vol. 3, Pg. 201, 1980.
mouse	LD50	intraperitoneal	360mg/kg (360mg/kg)		Journal of Medicinal Chemistry. Vol. 19, Pg. 918, 1976.
mouse	LD50	intravenous	275mg/kg (275mg/kg)		Journal of Medicinal Chemistry. Vol. 19, Pg. 918, 1976.
mouse	LD50	parenteral	264mg/kg (264mg/kg)		Cancer Chemotherapy Reports. Vol. 48, Pg. 1, 1965.
mouse	LD50	subcutaneous	335mg/kg (335mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat	LD50	intravenous	138mg/kg (138mg/kg)		Cancer Chemotherapy Reports. Vol. 29, Pg. 91, 1963.
women	LDLo	intravenous	440mg/kg/65W- (440mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Gut. Vol. 12, Pg. 717, 1971.
women	TDLo	intravenous	13513ug/kg (13.513mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	New England Journal of Medicine. Vol. 311, Pg. 798, 1984.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes:Xn,T
Risk Statements: 40-61-46-45-22-20/21/22 
R40:Limited evidence of a carcinogenic effect. 
R61:May cause harm to the unborn child. 
R46:May cause heritable genetic damage. 
R45:May cause cancer. 
R22:Harmful if swallowed. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37-53-45-36-22 
S36/37:Wear suitable protective clothing and gloves. 
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36:Wear suitable protective clothing. 
S22:Do not breathe dust.
RIDADR: 3249
WGK Germany: 3
RTECS: LZ5775000
F: 3-10-21
HazardClass: 6.1(b)
PackingGroup: III 

Standards and Recommendations：

 

Analytical Methods：