CAS No.:18559-63-2
Name: Tretoquinol dl-form hydrochloride
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 660mg/kg (660mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
| guinea pig | LD50 | oral | > 2gm/kg (2000mg/kg) | European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. | |
| mouse | LD50 | intraperitoneal | 340mg/kg (340mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
| mouse | LD50 | intravenous | 130mg/kg (130mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. | |
| mouse | LD50 | subcutaneous | 480mg/kg (480mg/kg) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 262, 1984. | |
| rat | LD50 | intraperitoneal | 311mg/kg (311mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
| rat | LD50 | intravenous | 174mg/kg (174mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
| rat | LD50 | oral | > 2gm/kg (2000mg/kg) | European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | European Journal of Pharmacology. Vol. 5, Pg. 303, 1968. |
Consensus Reports：
SAFETY PROFILE：
Poison by intravenous and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl. An adrenergic beta-stimulant. See also INOLIN.
Standards and Recommendations：
Analytical Methods：
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