CAS No.:52-68-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	37mg/kg (37mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat	LD50	oral	97mg/kg (97mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 60, 1982.
cat	LD50	unreported	98mg/kg (98mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Russian Pharmacology and Toxicology Vol. 50, Pg. 61, 1987.
chicken	LD50	oral	75mg/kg (75mg/kg)		Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
chicken	LD50	subcutaneous	125mg/kg (125mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)	Biochemical Pharmacology. Vol. 12, Pg. 1377, 1963.
dog	LD50	intravenous	150mg/kg (150mg/kg)	CARDIAC: OTHER CHANGES LIVER: OTHER CHANGES BLOOD: HEMORRHAGE	Archives of Toxicology. Vol. 41, Pg. 3, 1978.
dog	LD50	oral	400mg/kg (400mg/kg)	CARDIAC: OTHER CHANGES LIVER: OTHER CHANGES BLOOD: HEMORRHAGE	Archives of Toxicology. Vol. 41, Pg. 3, 1978.
dog	LD50	subcutaneous	269mg/kg (269mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: OTHER CHANGES	Revista do Centro de Ciencias Rurais Vol. 7(1), Pg. 23, 1977.
guinea pig	LD50	intraperitoneal	300mg/kg (300mg/kg)		AMA Archives of Industrial Health. Vol. 11, Pg. 53, 1955.
guinea pig	LDLo	oral	420mg/kg (420mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Bulletin of the University of Miami School of Medicine and Jackson Memorial Hospital. Vol. 9, Pg. 7, 1955.
hamster	LD50	intraperitoneal	1gm/kg (1000mg/kg)		Archives of Toxicology. Vol. 58, Pg. 152, 1986.
human	TCLo	inhalation	1710ug/m3/90D (1.71mg/m3)		British Journal of Industrial Medicine. Vol. 43, Pg. 414, 1986.
mammal (species unspecified)	LD50	skin	> 2800mg/kg (2800mg/kg)		Archives of Toxicology. Vol. 41, Pg. 3, 1978.
mammal (species unspecified)	LD50	unreported	295mg/kg (295mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(8), Pg. 101, 1973.
monkey	LD	oral	> 1gm/kg (1000mg/kg)	SPINAL CORD: OTHER DEGENERATIVE CHANGES MUSCULOSKELETAL: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES	Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
mouse	LD50	intraperitoneal	196mg/kg (196mg/kg)		Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960.
mouse	LD50	intravenous	290mg/kg (290mg/kg)	CARDIAC: OTHER CHANGES LIVER: OTHER CHANGES BLOOD: HEMORRHAGE	Archives of Toxicology. Vol. 41, Pg. 3, 1978.
mouse	LD50	oral	300mg/kg (300mg/kg)		Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 26, 1978.
mouse	LD50	skin	1710mg/kg (1710mg/kg)		Yakkyoku. Pharmacy. Vol. 37, Pg. 597, 1986.
mouse	LD50	subcutaneous	267mg/kg (267mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
mouse	LD50	unreported	445mg/kg (445mg/kg)		Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969.
quail	LD50	oral	73110ug/kg (73.11mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. Vol. 24, Pg. 35, 1974.
rabbit	LD	skin	> 1500mg/kg (1500mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(10), Pg. 54, 1964.
rabbit	LD50	intraperitoneal	60mg/kg (60mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	American Journal of Ophthalmology. Vol. 53, Pg. 512, 1962.
rabbit	LD50	oral	160mg/kg (160mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
rabbit	LDLo	intramuscular	500mg/kg (500mg/kg)	VASCULAR: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: HEMORRHAGE	Medycyna Weterynaryjna. Veterinary Medicine. Vol. 35, Pg. 479, 1979.
rat	LC50	inhalation	1300mg/m3 (1300mg/m3)		Archiv fuer Geschwulstforschung. Vol. 48, Pg. 112, 1978.
rat	LD50	intramuscular	395mg/kg (395mg/kg)	CARDIAC: OTHER CHANGES LIVER: OTHER CHANGES BLOOD: HEMORRHAGE	Archives of Toxicology. Vol. 41, Pg. 3, 1978.
rat	LD50	intraperitoneal	160mg/kg (160mg/kg)		Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat	LD50	oral	450mg/kg (450mg/kg)		United States Patent Document. Vol. #5006545,
rat	LD50	skin	2gm/kg (2000mg/kg)		Archiv fuer Geschwulstforschung. Vol. 48, Pg. 112, 1978.
rat	LD50	subcutaneous	400mg/kg (400mg/kg)		Journal of Economic Entomology. Vol. 50, Pg. 356, 1957.
rat	LD50	unreported	550mg/kg (550mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 21, 1982.
women	TDLo	oral	1mL/kg (1mL/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
women	TDLo	oral	1200uL/kg (1.2mL/kg)	SPINAL CORD: OTHER DEGENERATIVE CHANGES AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: COMA	Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
women	TDLo	oral	1364uL/kg (1.364mL/kg)	AUTONOMIC NERVOUS SYSTEM: GAGLION BLOCK BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SLEEP	Rinsho Shinkeigaku. Clinical Neurology. Vol. 21, Pg. 993, 1981.
women	TDLo	oral	240mg/kg (240mg/kg)	SPINAL CORD: OTHER DEGENERATIVE CHANGES PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: COMA	Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.

Consensus Reports：

 

SAFETY PROFILE：

Safety Information of Trichlorfon (CAS NO.52-68-6):
Hazard Codes: Xn,N
Risk Statements: 22-43-50/53
22:  Harmful if swallowed 
43:  May cause sensitization by skin contact 
50:  Very Toxic to aquatic organisms 
53:  May cause long-term adverse effects in the aquatic environment 
Safety Statements: 24-37-60-61-2
2:  Keep out of the reach of children 
24:  Avoid contact with skin 
37:  Wear suitable gloves 
60:  This material and/or its container must be disposed of as hazardous waste 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 

Standards and Recommendations：

 

Analytical Methods：