CAS No.:34758-84-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	154mg/kg/3D-I (154mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.
dog	LD50	oral	228mg/kg (228mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
dog	LDLo	intravenous	54600ug/kg (54.6mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
human	TDLo	oral	11mg/kg (11mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Lancet. Vol. 1, Pg. 45, 1984.
man	TDLo	oral	10714ug/kg (10.714mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.
mouse	LD50	intraperitoneal	116mg/kg (116mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse	LD50	intravenous	44300mg/kg (44300mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse	LD50	oral	300mg/kg (300mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
mouse	LD50	subcutaneous	158mg/kg (158mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rabbit	LD50	oral	173mg/kg (173mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	intraperitoneal	77600ug/kg (77.6mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	intravenous	32700ug/kg (32.7mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	oral	435mg/kg (435mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat	LD50	subcutaneous	139mg/kg (139mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
women	TDLo	oral	18mg/kg (18mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 45, 1984.

Consensus Reports：

 

SAFETY PROFILE：

Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and parenteral routes. Human systemic effects by ingestion: convulsions, coma. An antitussive agent. When heated to decomposition it emits toxic fumes of NO_x and ClH.

Standards and Recommendations：

 

Analytical Methods：