CAS No.:637-32-1
Name: 1-(p-CHLOROPHENYL)-5-ISOPROPYLBI GUANIDE HYDROCHLORIDE
Details Introduction
TOXICITY DATA with REFERENCE:
1. |
orl-rat LD50:58 mg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
2. |
ivn-rat LD50:33 mg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
3. |
orl-mus LD50:27 mg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
4. |
ivn-mus LD50:23 mg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
5. |
orl-rbt LD50:172 mg/kg |
BJPCAL British Journal of Pharmacology and Chemotherapy. 2 (1947),181. | ||
6. |
ivn-rbt LD50:44,850 µg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
7. |
ivn-gpg LD50:39,510 µg/kg |
JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157. | ||
8. |
orl-ckn LD50:400 mg/kg |
BJPCAL British Journal of Pharmacology and Chemotherapy. 2 (1947),181. |
Consensus Reports:
SAFETY PROFILE:
Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl− and NOx.Safety information of Proguanil hydrochloride (CAS NO.637-32-1):
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
Standards and Recommendations:
Analytical Methods:
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