CAS No.:19408-74-3
Name: 1,2,3,7,8,9-Hexachlorodibenzo-P-Dioxin
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 60ug/kg (0.06mg/kg) | Toxicology and Applied Pharmacology. Vol. 44, Pg. 335, 1978. | |
mouse | LD50 | oral | > 1440mg/kg (1440mg/kg) | Endocrine: changes in spleen weight endocrine: changes in thymus weight blood: "changes in serum composition (e.g., tp, bilirubin, cholesterol)" | Toxicology and Applied Pharmacology. Vol. 44, Pg. 335, 1978. |
Consensus Reports:
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 , 1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 , 1977,p. 41.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .
SAFETY PROFILE:
A poison by ingestion. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic vapors of Cl−.
RIDADR: 2811
HazardClass: 6.1(a)
PackingGroup: I
Standards and Recommendations:
Analytical Methods:
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