CAS No.:2365-30-2
Name: 1-(2-CHLOROETHYL)-1-NITROSOUREA
Details Introduction
TOXICITY DATA with REFERENCE:
1. | mmo-sat 1 µg/plate | MUREAV Mutation Research. 68 (1979),1. | ||
2. | mma-sat 20 nmol/plate | CNREA8 Cancer Research. 39 (1979),1328. | ||
3. | dnr-esc 1 mmol/L | CNREA8 Cancer Research. 45 (1985),6471. | ||
4. | dnd-hmn:ovr 50 µmol/L | INSSDM INSERM Symposium. 19 (1981),33. | ||
5. | dnd-mus:leu 10 µmol/L | CNREA8 Cancer Research. 43 (1983),175. | ||
6. | msc-ham:lng 10 µmol/L | CNREA8 Cancer Research. 40 (1980),2719. | ||
7. | ipr-mus LD50:4368 µg/kg | NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . | ||
8. | ivn-mus LD10:4700 µg/kg | ANBCB3 Antibiotics and Chemotherapy. 23 (1978),64. |
Consensus Reports:EPA Genetic Toxicology Program.
SAFETY PROFILE:
Poison by intraperitoneal and intravenous routes. Human mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
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