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Current position:Home > Products > 1-Phenyl-2-thiourea

CAS No.:103-85-5

Name: 1-Phenyl-2-thiourea

Details Introduction

TOXICITY DATA with REFERENCE:

 1-Phenyl-2-thiourea (103-85-5) is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 10mg/kg (10mg/kg)   Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
rabbit LD50 oral 40mg/kg (40mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.
rat LD50 intraperitoneal 5mg/kg (5mg/kg) ENDOCRINE: HYPERGLYCEMIA Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 186, 1947.
rat LD50 oral 3mg/kg (3mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.


Consensus Reports:

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-148 ,1978. . EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.


SAFETY PROFILE:

Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Safety Information of  1-Phenyl-2-thiourea (103-85-5):
Hazard Codes: T+
Risk Statements: 28-43
28:  Very Toxic if swallowed
43:  May cause sensitization by skin contact
Safety Statements: 28-36/37-45
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Standards and Recommendations:

 


Analytical Methods:

 


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