CAS No.:103-85-5
Name: 1-Phenyl-2-thiourea
Details Introduction
TOXICITY DATA with REFERENCE:
1-Phenyl-2-thiourea (103-85-5) is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | National Technical Information Service. Vol. AD277-689, | |
mouse | LD50 | oral | 10mg/kg (10mg/kg) | Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973, | |
rabbit | LD50 | oral | 40mg/kg (40mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961. | |
rat | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | ENDOCRINE: HYPERGLYCEMIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 186, 1947. |
rat | LD50 | oral | 3mg/kg (3mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961. |
Consensus Reports:
NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-148 ,1978. . EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Safety Information of 1-Phenyl-2-thiourea (103-85-5):
Hazard Codes: T+
Risk Statements: 28-43
28: Very Toxic if swallowed
43: May cause sensitization by skin contact
Safety Statements: 28-36/37-45
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Standards and Recommendations:
Analytical Methods:
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