CAS No.:7336-36-9
Name: 2-Demethylcolchicine
Details Introduction
TOXICITY DATA with REFERENCE：
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 16577ug/kg (16.577mg/kg) | Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981. | |
| mouse | LD50 | intraperitoneal | 16mg/kg (16mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957. |
| mouse | LD50 | oral | 19mg/kg (19mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 453, 1953. |
| rat | LDLo | intracrebral | 75ug/kg (0.075mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957. |
Consensus Reports：
SAFETY PROFILE：
Poison by ingestion, intramuscular, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Standards and Recommendations：
Analytical Methods：
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