CAS No.:298-46-4

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	19mg/kg/4W-I (19mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS	Pediatrics. Vol. 73, Pg. 841, 1984.
child	TDLo	oral	25926ug/kg (25.926mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 320, 1993.
child	TDLo	oral	55mg/kg (55mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 323, 2000.
child	TDLo	oral	65mg/kg (65mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Pediatrics. Vol. 121, Pg. 295, 1992.
child	TDLo	oral	420mg/kg/3W-I (420mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR BEHAVIORAL: GENERAL ANESTHETIC	Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 109, 1998.
child	TDLo	oral	1050mg/kg/6W- (1050mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Psychiatry. Vol. 143, Pg. 1176, 1985.
dog	LD50	oral	5620mg/kg (5620mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
guinea pig	LD50	oral	920mg/kg (920mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
human	TDLo	oral	43mg/kg (43mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 1, Pg. 754, 1977.
man	LDLo	oral	54mg/kg/9D-I (54mg/kg)	BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED BLOOD: AGRANULOCYTOSIS	Canadian Medical Association Journal. Vol. 132, Pg. 1040, 1985.
man	TDLo	oral	94mg/kg/11D-I (94mg/kg)	BLOOD: THROMBOCYTOPENIA	Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 305, 1990.
man	TDLo	oral	160mg/kg/3W-I (160mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of Clinical Pyschopharmacology. Vol. 5, Pg. 185, 1985.
man	TDLo	oral	253mg/kg/6W-I (253mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED	Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 251, 1986.
mouse	LD50	intraperitoneal	114mg/kg (114mg/kg)		Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.
mouse	LD50	oral	529mg/kg (529mg/kg)		Farmaco. Vol. 44, Pg. 595, 1989.
mouse	LD50	subcutaneous	> 1gm/kg (1000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.
rabbit	LD50	oral	2680mg/kg (2680mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
rat	LD50	intraperitoneal	158mg/kg (158mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 202, Pg. 106, 1973.
rat	LD50	oral	1957mg/kg (1957mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Japanese Kokai Tokyo Koho Patents. Vol. #79-163823,
rat	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.
women	LDLo	oral	1920mg/kg/17W (1920mg/kg)	BLOOD: APLASTIC ANEMIA	American Journal of Psychiatry. Vol. 142, Pg. 974, 1985.
women	TDLo	oral	28mg/kg/4D-I (28mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Psychiatry. Vol. 143, Pg. 1328, 1986.
women	TDLo	oral	112mg/kg/2W-I (112mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: THROMBOCYTOPENIA	American Journal of Psychiatry. Vol. 150, Pg. 1750, 1993.
women	TDLo	oral	144mg/kg/2W-I (144mg/kg)	BLOOD: THROMBOCYTOPENIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Journal of Clinical Psychiatry. Vol. 53, Pg. 378, 1992.
women	TDLo	oral	560mg/kg/4W-I (560mg/kg)	BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	British Journal of Clinical Practice. Vol. 43, Pg. 302, 1989.
women	TDLo	oral	7604mg/kg/69W (7604mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Japanese Heart Journal. Vol. 39, Pg. 469, 1998.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn
Risk Statements: 42/43-22-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R22:Harmful if swallowed. 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 37-24-22-36/37/39-36
S22:Do not breathe dust. 
S24:Avoid contact with skin. 
S36:Wear suitable protective clothing. 
S37:Wear suitable gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 

Standards and Recommendations：

 

Analytical Methods：