CAS No.:113-52-0

TOXICITY DATA with REFERENCE：

1.		dni-oin-unr 10 g/L		JCLBA3    Journal of Cell Biology. 47 (1970),182a.
2.		cyt-oin-unr 10 g/L		JCLBA3    Journal of Cell Biology. 47 (1970),182a.
3.		orl-man TDLo:2143 µg/kg/2D-I		JCLPDE    Journal of Clinical Psychiatry. 44 (1983),225.
4.		orl-chd TDLo:25 mg/kg:CNS,PUL		JAMAAP    JAMA, Journal of the American Medical Association. 179 (1962),456.
5.		orl-chd LDLo:15 mg/kg		BMJOAE    British Medical Journal. 1 (1974),261.
6.		orl-chd TDLo:27 mg/kg:CNS,KID		JAMAAP    JAMA, Journal of the American Medical Association. 230 (1974),1405.
7.		orl-wmn TDLo:107 mg/kg:CNS,CVS		NEJMAG    New England Journal of Medicine. 268 (1963),33.
8.		orl-wmn TDLo:30 mg/kg:PNS,CNS		BMJOAE    British Medical Journal. 2 (1959),1458.
9.		orl-rat LD50:305 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
10.		ipr-rat LD50:72 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 21 (1971),391.
11.	&nb

Consensus Reports：Reported in EPA TSCA Inventory.
SAFETY PROFILE：
Human poison by ingestion. An experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: sleep, somnolence, convulsions, muscle contraction or spasticity, coma, blood pressure decrease, dyspnea (difficulty in breathing), paresthesia (abnormal sensations), and kidney changes. Experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of NO_x and HCl. See also DIAZEPAM.