CAS No.:137-58-6

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	21mg/kg (21mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992.
child	TDLo	oral	300mg/kg/5D-I (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Pediatric Emergency Care. Vol. 10, Pg. 344, 1994.
guinea pig	LD50	subcutaneous	120mg/kg (120mg/kg)		Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955.
guinea pig	LDLo	intravenous	65mg/kg (65mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961.
human	TDLo	intravenous	23mg/kg (23mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971.
man	TDLo	intravenous	1700ug/kg/2M- (1.7mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE	American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986.
man	TDLo	intravenous	8643ug/kg/4H- (8.643mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 97, Pg. 149, 1982.
mouse	LD50	intraperitoneal	102mg/kg (102mg/kg)	PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958.
mouse	LD50	oral	220mg/kg (220mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966.
mouse	LD50	subcutaneous	238mg/kg (238mg/kg)		Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit	LDLo	intravenous	41mg/kg (41mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat	LD50	intraperitoneal	133mg/kg (133mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980.
rat	LD50	intravenous	18mg/kg (18mg/kg)		United States Patent Document. Vol. #5264432,
rat	LD50	oral	317mg/kg (317mg/kg)		Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat	LD50	subcutaneous	335mg/kg (335mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974.
rat	LD50	unreported	39400ug/kg (39.4mg/kg)		Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991.
women	TDLo	intraspinal	1mL/kg (1mL/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990.
women	TDLo	intravenous	16mg/kg (16mg/kg)	CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982.
women	TDLo	oral	39mg/kg (39mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT CARDIAC: CHANGE IN RATE	New England Journal of Medicine. Vol. 306, Pg. 381, 1982.

Consensus Reports：

Reported in EPA TSCA Inventory.

SAFETY PROFILE：

Safety Information of Lidocaine (CAS NO.137-58-6):
Hazard Codes:Xn
Risk Statements:22
R22:Harmful if swallowed 
Safety Statements:22-26-36
S22:Do not breathe dust
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing     
RIDADR:3249
WGK Germany:3
RTECS:AN7525000
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: blood pressure lowering, changes in heart rate, coma, convulsions, distorted perceptions, dyspnea, excitement, hallucinations, muscle contraction or spasticity, pulse rate, respiratory depression, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. A local anesthetic. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Standards and Recommendations：

 

Analytical Methods：