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Current position:Home > Products > Lidocaine

CAS No.:137-58-6

Name: Lidocaine

Details Introduction

TOXICITY DATA with REFERENCE:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 21mg/kg (21mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992.
child TDLo oral 300mg/kg/5D-I (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Pediatric Emergency Care. Vol. 10, Pg. 344, 1994.
guinea pig LD50 subcutaneous 120mg/kg (120mg/kg)   Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955.
guinea pig LDLo intravenous 65mg/kg (65mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961.
human TDLo intravenous 23mg/kg (23mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971.
man TDLo intravenous 1700ug/kg/2M- (1.7mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE
American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986.
man TDLo intravenous 8643ug/kg/4H- (8.643mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Annals of Internal Medicine. Vol. 97, Pg. 149, 1982.
mouse LD50 intraperitoneal 102mg/kg (102mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958.
mouse LD50 oral 220mg/kg (220mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966.
mouse LD50 subcutaneous 238mg/kg (238mg/kg)   Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit LDLo intravenous 41mg/kg (41mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat LD50 intraperitoneal 133mg/kg (133mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980.
rat LD50 intravenous 18mg/kg (18mg/kg)   United States Patent Document. Vol. #5264432,
rat LD50 oral 317mg/kg (317mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat LD50 subcutaneous 335mg/kg (335mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974.
rat LD50 unreported 39400ug/kg (39.4mg/kg)   Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991.
women TDLo intraspinal 1mL/kg (1mL/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990.
women TDLo intravenous 16mg/kg (16mg/kg) CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982.
women TDLo oral 39mg/kg (39mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

CARDIAC: CHANGE IN RATE
New England Journal of Medicine. Vol. 306, Pg. 381, 1982.


Consensus Reports:

Reported in EPA TSCA Inventory.


SAFETY PROFILE:

Safety Information of Lidocaine (CAS NO.137-58-6):
Hazard Codes:HarmfulXn
Risk Statements:22
R22:Harmful if swallowed 
Safety Statements:22-26-36
S22:Do not breathe dust
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing     
RIDADR:3249
WGK Germany:3
RTECS:AN7525000
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: blood pressure lowering, changes in heart rate, coma, convulsions, distorted perceptions, dyspnea, excitement, hallucinations, muscle contraction or spasticity, pulse rate, respiratory depression, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. A local anesthetic. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.


Standards and Recommendations:

 


Analytical Methods:

 


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