CAS No.:137-58-6
Name: Lidocaine
Details Introduction
TOXICITY DATA with REFERENCE:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 21mg/kg (21mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992. |
child | TDLo | oral | 300mg/kg/5D-I (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Pediatric Emergency Care. Vol. 10, Pg. 344, 1994. |
guinea pig | LD50 | subcutaneous | 120mg/kg (120mg/kg) | Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955. | |
guinea pig | LDLo | intravenous | 65mg/kg (65mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961. | |
human | TDLo | intravenous | 23mg/kg (23mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971. |
man | TDLo | intravenous | 1700ug/kg/2M- (1.7mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE |
American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986. |
man | TDLo | intravenous | 8643ug/kg/4H- (8.643mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Annals of Internal Medicine. Vol. 97, Pg. 149, 1982. |
mouse | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981. |
mouse | LD50 | intravenous | 20mg/kg (20mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958. |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966. |
mouse | LD50 | subcutaneous | 238mg/kg (238mg/kg) | Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985. | |
rabbit | LDLo | intravenous | 41mg/kg (41mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. | |
rat | LD50 | intraperitoneal | 133mg/kg (133mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980. |
rat | LD50 | intravenous | 18mg/kg (18mg/kg) | United States Patent Document. Vol. #5264432, | |
rat | LD50 | oral | 317mg/kg (317mg/kg) | Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971. | |
rat | LD50 | subcutaneous | 335mg/kg (335mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974. | |
rat | LD50 | unreported | 39400ug/kg (39.4mg/kg) | Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991. | |
women | TDLo | intraspinal | 1mL/kg (1mL/kg) | BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" |
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990. |
women | TDLo | intravenous | 16mg/kg (16mg/kg) | CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982. |
women | TDLo | oral | 39mg/kg (39mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT CARDIAC: CHANGE IN RATE |
New England Journal of Medicine. Vol. 306, Pg. 381, 1982. |
Consensus Reports:
Reported in EPA TSCA Inventory.
SAFETY PROFILE:
Safety Information of Lidocaine (CAS NO.137-58-6):
Hazard Codes:Xn
Risk Statements:22
R22:Harmful if swallowed
Safety Statements:22-26-36
S22:Do not breathe dust
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
RIDADR:3249
WGK Germany:3
RTECS:AN7525000
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: blood pressure lowering, changes in heart rate, coma, convulsions, distorted perceptions, dyspnea, excitement, hallucinations, muscle contraction or spasticity, pulse rate, respiratory depression, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. A local anesthetic. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Standards and Recommendations:
Analytical Methods:
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