CAS No.:50-07-7

TOXICITY DATA with REFERENCE：

 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	7500ug/kg (7.5mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat	LDLo	intravenous	2500ug/kg (2.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Cancer Research. Vol. 20, Pg. 1354, 1960.
dog	LD50	intravenous	720ug/kg (0.72mg/kg)		Drugs in Japan Vol. -, Pg. 1129, 1990.
man	TDLo	unreported	1350ug/kg/21W (1.35mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: NORMOCYTIC ANEMIA	Archives of Internal Medicine. Vol. 143, Pg. 803, 1983.
monkey	LDLo	intravenous	1mg/kg (1mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Cancer Research. Vol. 20, Pg. 1354, 1960.
mouse	LD50	intraperitoneal	4mg/kg (4mg/kg)		Journal of Antibiotics, Series A. Vol. 13, Pg. 27, 1960.
mouse	LD50	intravenous	4mg/kg (4mg/kg)		Journal of Antibiotics, Series A. Vol. 13, Pg. 27, 1960.
mouse	LD50	oral	23mg/kg (23mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Cancer Research. Vol. 20, Pg. 1354, 1960.
mouse	LD50	subcutaneous	7300ug/kg (7.3mg/kg)		Japanese Journal of Cancer Research. Vol. 80, Pg. 670, 1989.
mouse	LD50	unreported	12mg/kg (12mg/kg)		Cancer Research. Vol. 46, Pg. 2703, 1986.
mouse	LDLo	intratracheal	4mg/kg (4mg/kg)		Toxicology Letters. Vol. 30, Pg. 63, 1986.
quail	LD50	oral	> 100mg/kg (100mg/kg)		Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rabbit	LD50	intravenous	3400ug/kg (3.4mg/kg)		Drugs in Japan Vol. -, Pg. 1129, 1990.
rat	LD50	intraperitoneal	2mg/kg (2mg/kg)		Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat	LD50	intravenous	3mg/kg (3mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat	LD50	oral	30mg/kg (30mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Cancer Research. Vol. 20, Pg. 1354, 1960.
rat	LD50	subcutaneous	3250ug/kg (3.25mg/kg)		Drugs in Japan Vol. 6, Pg. 798, 1982.
women	TDLo	intravenous	1800ug/kg (1.8mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Lancet. Vol. 2, Pg. 1037, 1980.
women	TDLo	unreported	2100ug/kg/40W (2.1mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA BLOOD: OTHER CHANGES	Archives of Internal Medicine. Vol. 143, Pg. 1617, 1983.

Consensus Reports：

 

SAFETY PROFILE：

 Hazard Codes T,T+,Xn
Risk Statements 25-40-22-45-26/27/28
R25 :Toxic if swallowed.
R40:Limited evidence of a carcinogenic effect.
R22:Harmful if swallowed.
R45:May cause cancer.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements 36/37-45-28-53-22
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S28:After contact with skin, wash immediately with plenty of soap-suds.
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS CN0700000
F 8-10
HazardClass 6.1(a)
PackingGroup II

Standards and Recommendations：

 

Analytical Methods：