CAS No.:13292-46-1

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	639mg/kg (639mg/kg)		Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
human	TDLo	oral	180mg/kg (180mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 2, Pg. 1189, 1977.
man	LDLo	oral	857mg/kg (857mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	JAMA, Journal of the American Medical Association. Vol. 240, Pg. 2283, 1978.
man	TDLo	oral	13mg/kg/2D (13mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	British Medical Journal. Vol. 1, Pg. 199, 1976.
man	TDLo	oral	814mg/kg/15W- (814mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA	American Journal of Kidney Diseases. Vol. 32, Pg. 533, 1998.
mouse	LD50	intraperitoneal	416mg/kg (416mg/kg)		Chemotherapia. Vol. 12, Pg. 155, 1967.
mouse	LD50	intravenous	260mg/kg (260mg/kg)		Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
mouse	LD50	oral	500mg/kg (500mg/kg)		Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. Vol. 269, Pg. 2147, 1969.
mouse	LD50	subcutaneous	621mg/kg (621mg/kg)		Japanese Journal of Antibiotics. Vol. 23, Pg. 242, 1970.
rabbit	LD50	oral	2120mg/kg (2120mg/kg)		Antibiotica et Chemotherapia Vol. 16, Pg. 316, 1970.
rat	LD50	intraperitoneal	511mg/kg (511mg/kg)		Japanese Journal of Antibiotics. Vol. 23, Pg. 257, 1970.
rat	LD50	oral	1570mg/kg (1570mg/kg)		Japanese Journal of Antibiotics. Vol. 23, Pg. 257, 1970.
rat	LD50	subcutaneous	534mg/kg (534mg/kg)		Japanese Journal of Antibiotics. Vol. 23, Pg. 242, 1970.
women	TDLo	oral	315mg/kg/5W-I (315mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of the American Academy of Dermatology. Vol. 17, Pg. 303, 1987.
women	TDLo	oral	504mg/kg/42D- (504mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: APLASTIC ANEMIA	American Journal of Medicine. Vol. 87, Pg. 459, 1989.
women	TDLo	oral	744mg/kg/9W-I (744mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Kidney Diseases. Vol. 31, Pg. 108, 1998.

Consensus Reports：

 

SAFETY PROFILE：

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-36/38
 R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37/39:Wear suitable gloves and eye/face protection.

Standards and Recommendations：

 

Analytical Methods：