CAS No.:130-61-0

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	160mg/kg (160mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	33mg/kg (33mg/kg)		Therapie. Vol. 14, Pg. 793, 1959.
mouse	LD50	oral	360mg/kg (360mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit	LD50	intravenous	26mg/kg (26mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit	LD50	oral	1100mg/kg (1100mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat	LD50	intravenous	71mg/kg (71mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat	LD50	oral	1060mg/kg (1060mg/kg)		Drugs in Japan Vol. 6, Pg. 458, 1982.
women	TDLo	oral	864mg/kg/18D- (864mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984.

Consensus Reports：

EPA Genetic Toxicology Program.

SAFETY PROFILE：

Poison by ingestion and intravenous routes. Human systemic effects: evidence of thyroid hyperfunction, increased body temperature, pulse rate increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x, SO_x, and HCl.
Hazard Codes: Xn,N
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S60: This material and its container must be disposed of as hazardous waste. 
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.

Standards and Recommendations：

 

Analytical Methods：