CAS No.:146-22-5

TOXICITY DATA with REFERENCE：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	11mg/kg (11mg/kg)	BEHAVIORAL: EXCITEMENT VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996.
mouse	LD50	intraperitoneal	275mg/kg (275mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972.
mouse	LD50	intravenous	130mg/kg (130mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01434,
mouse	LD50	oral	550mg/kg (550mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3206-79,
mouse	LD50	subcutaneous	> 400mg/kg (400mg/kg)	BEHAVIORAL: EXCITEMENT	Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965.
rabbit	LD50	intravenous	520mg/kg (520mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972.
rabbit	LD50	oral	520mg/kg (520mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965.
rat	LD50	intraperitoneal	733mg/kg (733mg/kg)	BEHAVIORAL: ANTICONVULSANT	Journal of Medicinal Chemistry. Vol. 20, Pg. 952, 1977.
rat	LD50	oral	825mg/kg (825mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Consensus Reports：

EPA Genetic Toxicology Program.

SAFETY PROFILE：

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5):
Hazard Codes: Xn
Risk Statements: 22 
R22:Harmful if swallowed.
Safety Statements: 36/37/39 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 3249
WGK Germany: 3
RTECS: DF2450000
HazardClass: 6.1(b)
PackingGroup: III 

Standards and Recommendations：

 

Analytical Methods：