CAS No.:60784-46-5
Name: 1-(2-CHLOROETHYL)-3-(2-HYDROXYETHYL)-1-NITROSOUREA
Details Introduction
TOXICITY DATA with REFERENCE:
1. | sln-dmg-orl 5 mmol/L | DRISAA Drosophila Information Service. 52 (1977),20. | ||
2. | sln-dmg-par 5 mmol/L | DRISAA Drosophila Information Service. 52 (1977),20. | ||
3. | mrc-smc 1 mmol/L/16H | MUREAV Mutation Research. 42 (1977),45. | ||
4. | dnd-rat-ipr 100 µmol/kg | CNREA8 Cancer Research. 44 (1984),514. | ||
5. | cyt-mus:lng 1 mg/L/1H | MUREAV Mutation Research. 44 (1977),87. | ||
6. | ivn-rat TDLo:16 mg/kg/60W-I:ETA | DTESD7 Developments in Toxicology and Environmental Science. 8 (1980),273. | ||
7. | ipr-rat LD50:25,300 µg/kg | ONCOBS Oncology. 37 (1980),177. | ||
8. | ipr-mus LD50:25 mg/kg | INSSDM INSERM Symposium. 19 (1981),123. |
Consensus Reports:EPA Genetic Toxicology Program.
SAFETY PROFILE:
Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
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