CAS No.:13909-09-6

TOXICITY DATA with REFERENCE：

1.		skn-rbt 5 mg/24H rns		TXCYAC    Toxicology. 14 (1979),117.
2.		mmo-sat 100 nmol/plate		JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
3.		mma-sat 100 nmol/plate		JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
4.		dnd-esc 50 µmol/L		MUREAV    Mutation Research. 89 (1981),95.
5.		dni-mus:oth 10 µmol/L		CNREA8    Cancer Research. 43 (1983),5837.
6.		orl-hmn TDLo:22 mg/kg/60W-C:CAR		NEJMAG    New England Journal of Medicine. 309 (1983),1079.
7.		ipr-rat TDLo:30 mg/kg/7W-I:CAR		CANCAR    Cancer. 40 (Suppl 4)(1977),1935.
8.		orl-hmn TDLo:90 mg/kg:BLD,GIT		CCYPBY    Cancer Chemotherapy Reports, Part 3. 4 (1973),257.
9.		orl-hmn TDLo:6 mg/kg:GIT,BLD		CTRRDO    Cancer Treatment Reports. 60 (1976),709.
10.		orl-chd LDLo:5550 mg/kg/30W-I		NEJMAG    New England Journal of Medicine. 300 (1979),1200.
11.		orl-chd TDLo:37,950&

Consensus Reports：

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 150.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence 7,150,87; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 150.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: rat CANCAR    Cancer. 40 (1977),1935. ; No Evidence: mouse CANCAR    Cancer. 40 (1977),1935. .

SAFETY PROFILE：

Confirmed human carcinogen producing leukemia. Experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, intravenous, and possibly other routes. Mutation data reported. Human systemic effects by ingestion: nausea or vomiting, damage to kidney tubules and glomeruli, and hematuria (blood in the urine). When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also N-NITROSO COMPOUNDS.Safety information of Semustine (CAS NO.13909-09-6):
Hazard Codes  T
Risk Statements 
45 May cause cancer
46 May cause heritable genetic damage
23/24/25 Toxic by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  3249
WGK Germany  3
RTECS  YS5000000
HazardClass  6.1(a)
PackingGroup  II

Standards and Recommendations：

 

Analytical Methods：